Uplifting News

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The original was posted on /r/upliftingnews by /u/Fun-Independent-3606 on 2025-07-30 08:28:59+00:00.

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The original was posted on /r/upliftingnews by /u/AdTrue3704 on 2025-07-30 05:13:31+00:00.

Gene therapy has been the future of otology and audiology for many years and I’m so excited that it is now finally here

Manohar Bance

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The original was posted on /r/upliftingnews by /u/frankipranki on 2025-07-31 22:12:21+00:00.

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The original was posted on /r/upliftingnews by /u/Plastic_Yak3792 on 2025-07-30 08:54:41+00:00.

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The original was posted on /r/upliftingnews by /u/Upstairs_Drive_5602 on 2025-07-30 07:21:38+00:00.

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The original was posted on /r/upliftingnews by /u/Beratungsmarketing on 2025-07-30 03:32:50+00:00.

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The original was posted on /r/upliftingnews by /u/Content-Word-7673 on 2025-07-30 03:12:14+00:00.

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The original was posted on /r/upliftingnews by /u/Bokbreath on 2025-07-29 23:32:32+00:00.

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The original was posted on /r/upliftingnews by /u/Fun-Independent-3606 on 2025-07-29 23:24:47+00:00.

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The original was posted on /r/upliftingnews by /u/intellectual_punk on 2025-07-29 13:51:23+00:00.

"The UN’s principal judicial body ruled that States have an obligation to protect the environment from greenhouse gas (GHG) emissions and act with due diligence and cooperation to fulfill this obligation.  

This includes the obligation under the Paris Agreement on climate change to limit global warming to 1.5°C above pre-industrial levels.  

The Court further ruled that if States breach these obligations, they incur legal responsibility and may be required to cease the wrongful conduct, offer guarantees of non-repetition and make full reparation depending on the circumstances. "

I would be very interested to know how they plan to enforce this

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The original was posted on /r/upliftingnews by /u/sparki_black on 2025-07-30 14:35:08+00:00.

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The original was posted on /r/upliftingnews by /u/AdSpecialist6598 on 2025-07-29 12:50:58+00:00.

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The original was posted on /r/upliftingnews by /u/cwningen95 on 2025-07-29 02:28:38+00:00.

I remember being really touched by Trishna and Krishna's story when I saw a documentary on them a few years ago. I randomly decided to check if there were any updates on how they were doing, and came to find an interview with now-18 year old Trishna from just four weeks ago!

If the video in the article doesn't work (which it didn't for me), it can also be found on YouTube.

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The original was posted on /r/upliftingnews by /u/CupidStunt13 on 2025-07-28 23:58:06+00:00.

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The original was posted on /r/upliftingnews by /u/DoNotKnowJack on 2025-07-28 20:42:13+00:00.

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The original was posted on /r/upliftingnews by /u/isle_say on 2025-07-28 16:07:57+00:00.

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The original was posted on /r/upliftingnews by /u/AdSpecialist6598 on 2025-07-28 13:16:31+00:00.

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The original was posted on /r/upliftingnews by /u/GanterOfTanseng on 2025-07-28 07:56:29+00:00.

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The original was posted on /r/upliftingnews by /u/AppealPractical2942 on 2025-07-27 12:37:16+00:00.

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The original was posted on /r/upliftingnews by /u/Beratungsmarketing on 2025-07-28 03:49:11+00:00.

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The original was posted on /r/upliftingnews by /u/No-Zucchini3759 on 2025-07-26 18:52:19+00:00.

Here is the paper summary:

"In cancer cachexia, the presence of a tumor triggers systemic metabolic disruption that leads to involuntary body weight loss and accelerated mortality in affected patients. Here, we conducted transcriptomic and epigenomic profiling of the liver in various weight-stable cancer and cancer cachexia models. An integrative multilevel analysis approach identified a distinct gene expression signature that included hepatocyte-secreted factors and the circadian clock component REV-ERBα as key modulator of hepatic transcriptional reprogramming in cancer cachexia. Notably, hepatocyte-specific genetic reconstitution of REV-ERBα in cachexia ameliorated peripheral tissue wasting. This improvement was associated with decreased levels of specific cachexia-controlled hepatocyte-secreted factors. These hepatokines promoted catabolism in multiple cell types and were elevated in cachectic cancer patients. Our findings reveal a mechanism by which the liver contributes to peripheral tissue wasting in cancer cachexia, offering perspectives for future therapeutic interventions."

Here is my take on this:

• It identifies new therapeutic targets like REV-ERBα and specific hepatokines which reversed tissue wasting in animal models. This opens the door to treatments that actually work, which cachexia research has long needed.
• It shows that these targets are relevant across multiple types of cancer, meaning it’s not confined to one niche. That expands its reach to oncology, nutrition, palliative care, and metabolic medicine.
• It introduces biomarkers that could allow clinicians to detect cachexia early, giving insight into molecular behavior of the patient, instead of waiting to see the visible signs months down the road.

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The original was posted on /r/upliftingnews by /u/AdSpecialist6598 on 2025-07-27 13:30:11+00:00.

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The original was posted on /r/upliftingnews by /u/Aralknight on 2025-07-27 10:44:10+00:00.

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The original was posted on /r/upliftingnews by /u/guanaco55 on 2025-07-27 03:03:15+00:00.

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The original was posted on /r/upliftingnews by /u/Beratungsmarketing on 2025-07-26 11:25:46+00:00.