Clue would be fun as a season of alternate timelines, like how the game works. There's always a high-class mid-century party where someone ends up dead. Same setting, same characters, usually the same victim... but significant variation in backstory and circumstances.

One bit that's only possible in this format is replacing an actor for an episode. Professor Plum shows up and he's looking a lot more caucasian than usual. We the audience know he's not the real guy, but the characters have the usual exchanges. 'Have you met him before?' 'No, only read his work.' You could even do a double red herring, where fake Plum did not kill Mister Boddy... because Mister Boddy is not dead. But the real Plum is.