Just played this one for the first time. Danger 3. It was one of the easiest runs I had, but I also got lucky with the items. I started with a slingshot, and didn't know which stats to upgrade, but because the many enemies made up for the decreasing harvesting easily, I didn't try to go that route. I took a bit of everything (Max HP, HP Regen, Ranged DMG, Dodge, Luck).
I got two coupons very soon and a piggy bank, to bankroll me. I found 3 elephants and 2 cyberballs to make sure that the enemies just exploded away. I also had 1 sausage and 2 wolf helmet to incinerate the stronger enemies, as well as 3 alien eyes with high HP. Plus some cursed items (including one IV Slingshot, which dealt double the DMG of a normal IV Slingshot).
Actually, the mid boss I struggled a bit, but the endboss just fell like pudding.
This one is fun, and I can't wait to use Rip and Tear for a melee character, as I love elephants on luck builds.