Nope, no issues.
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Depending on how you configure it you can run into issues with sites and apps that use trackers.
I've seen it cause issues when you try and use Google Analytics console. You can add white list entries to groups and then add devices to that group. Works well.
Just make sure you have port 53 and 80 open. I recently had some problems myself trying to get Pi-Hole up and running. I already had dnsmasq taking up port 53 for a wifi hotspot, which conflicts with Pi-Hole's own DNS. Aside from that, hosting any websites can also conflict with Pi-Hole's frontend.
If you aren't using your Pi 3 for anything yet then I already assume this shouldn't be a problem though.
Good luck and have fun setting up your Pi-Hole!
I can’t think of any problems I’ve faced in over 3 years. I have an app on my phone that I can use to temporarily disable my Pi-hole if I need to do some testing, but I don’t know if I’ve ever had a situation where the Pi-hole was the source of a problem. Definitely not a maintenance headache. I run an update on it every now and then, but only because I see a notification that there is one, not because there’s something going wrong.