After my initial Space Age playthrough I started optimising for a while to hit 10k eSPM (i.e. after production bonuses / biolab usage reduction). Hit that and stopped playing for a while. Now returned to push to 100k eSPM with 10k+ raw SPM this time.

I am focusing on sciences needed for Mining productivity - those are really used a lot more consistently and the mining productivity is actually very helpful. Everything else I can mostly just stockpile for a while to still hit some high infinite sciences. I think I am hitting a stage there though where I'll need to put some more effort into some other sciences