Came across this tool randomly while modding skyrim and trying to find out how to get synthesis working through wine as i was having issues. This program is an appimage with a gui to allow you to set up and manage different instances of mo2 for various games as well as vortex mod manager too if you prefer that instead

it works pretty good some menus seem a bit buggier than on the prefix i had but generally across the board it works and the faq has dependencies and other info listed too! thought i would share because I'm surprised I've not seen it mentioned anywhere i just had the github appear at the top of my search when searching about synthesis.