this post was submitted on 18 Nov 2025
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DIY HRT

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Hi, I'm currently planning to try DIY by using spray. Anyone experiences with that?

If so:

How much do you try and where do you apply it?

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[–] WillStealYourUsername@piefed.blahaj.zone 2 points 1 month ago* (last edited 1 month ago)

I was sure there were papers on this but I might be mixing up what I've read about oral and sublingual with transdermal E.

I do know it's common to take gel more than once a day, but I can't actually back up the usefulness of doing this. It depends entirely on the half life of E when taken transdermally.

Here's a page which touches on this with oral and sublingual: https://transfemscience.org/articles/sublingual-e2-transfem/

Two pages on transdermal. They don't talk too much about half life here.
https://transfemscience.org/articles/oral-vs-transdermal-e2/
https://transfemscience.org/articles/high-dose-transdermal-e2/

I am certain it would result in more stable levels to take your dose split over the day, but the big question is if your levels go low enough over 24 hours for this to be necessary.

Edit: Also, since you're on a blocker you don't need high levels in order to suppress T so you have a larger range of good levels of E.