this post was submitted on 18 Nov 2025
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DIY HRT
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This community exists for trans people and others to give each other advice and support regarding HRT.
Keep in mind that none of us are doctors. Read up on how to do things properly and double check any advice you are given.
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Quick Facts
- Different routes (oral vs injections vs trans-dermal etc) have the same results. Pick whichever option you are most comfortable with.
- If you're doing feminizing hrt your boobs will randomly grow in bursts. Chest pain going away is perfectly normal.
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I was sure there were papers on this but I might be mixing up what I've read about oral and sublingual with transdermal E.
I do know it's common to take gel more than once a day, but I can't actually back up the usefulness of doing this. It depends entirely on the half life of E when taken transdermally.
Here's a page which touches on this with oral and sublingual: https://transfemscience.org/articles/sublingual-e2-transfem/
Two pages on transdermal. They don't talk too much about half life here.
https://transfemscience.org/articles/oral-vs-transdermal-e2/
https://transfemscience.org/articles/high-dose-transdermal-e2/
I am certain it would result in more stable levels to take your dose split over the day, but the big question is if your levels go low enough over 24 hours for this to be necessary.
Edit: Also, since you're on a blocker you don't need high levels in order to suppress T so you have a larger range of good levels of E.