The instance seems to be mostly right wing trolls. I know defederating is unpopular but I don't think much is to be lost in this case and it can save the mods some headaches.
Edit: the response on exploding-heads.com to my reporting of transphobia. Courtesy of the "second in command"
What's that old saying... "You can't reason with somebody who is in a position they didn't reason themselves into". They're not willing to change their minds or have a real discussion, the goalposts will just be moved time and time again when their hateful ideas are challenged.