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Depends on the nature of the disability I would say.
A neurological disorder of some sort or some other difference would likely not be curable but some sort of magical item could assist, rather than completely 'fix' the issue. It would be kind of fun to see how a high charisma character with autism handles things though.
Mobility issues could be routed around with enchantments and such or the use of some kind of frame or wheelchair even. Something fancy or something crudely constructed.