ForestOrca

FMSHBR 5/22 RYWT 7PM Light up your bikes and RIDE! Social paced no drop bike ride.

Full Moon Super Hero Bike Ride TONIGHT! Meetup 7pm at the Railyard Water Tower, for an amusing comedy skit on wheels. Light up your bikes, finish up your month's quota of vanquishing EVIL, and join us! This is a no drop social paced ride.

#SantaFe

https://pubmed.ncbi.nlm.nih.gov/37702115/

12 noon meetup at the Railyard Water Tower
12:30 Rollout

Molecular Jackhammers Eradicate Cancer Cells by Vibronic-Driven Action: https://www.biorxiv.org/content/10.1101/2023.01.25.525400v1

Abstract

Through the actuation of vibronic modes in cell-membrane-associated aminocyanines, a new type of molecular mechanical action can be exploited to rapidly kill cells by necrosis. This is done using near-infrared light, a low energy source hitherto thought to be insufficient to permit molecular mechanical disruption of a cell membrane. Vibronic-driven action (VDA) is distinct from both photodynamic therapy and photothermal therapy in that the VDA mechanical effect on the cell membrane is not retarded by high doses of inhibitors of reactive oxygen species (ROS), and VDA does not itself induce an increase in the temperature of the media; it is also unaffected by cooling the media to 2 °C. The picosecond concerted whole-molecule-vibrations of VDA-induced mechanical disruption can be done with very low concentrations (500 nM) of the aminocyanines or low doses of light (12 Jcm-2, 80 mWcm-2 for 2.5 min) to cause in vitro necrotic cell death in >99% of human melanoma cells. The effect is also studied in vivo in murine B16-F10 and human A375 melanoma in mice, underscoring the high efficiency of this approach, achieving a survival rate of 60% at day 120, and 50% of the mice becoming tumor free. The molecules that destroy cell membranes through VDA are termed molecular jackhammers (MJH) because they undergo concerted whole-molecule vibrations. Different than traditional chemotherapy, it is unlikely that a cell could develop a resistance to molecular mechanical forces, thereby providing a new modality for inducing cancer cell death.

Note: From further down in the paper, "While UV and visible light have only hundreds of microns to 1 mm of light penetration
through human tissue (skin, muscle, fat), the NIR window of 650 nm to 900 nm, also known as
the optical therapeutic window, is ideally suited for in vivo applications because of minimal light
absorption by hemoglobin and water with significant penetration through human tissue reaching
~10 cm.5" They are using NIR light to drive 2-3 MHx unidirectional rotation in these molecular motors, which create "drilling action on cellular membranes develop holes in the cell, then blebbing
and death within seconds to minutes of activation."

Welcome to Christmas Eve in O’ga P’ogeh

Join our Ceasefire Caroling

Scan code or visit: nnmsurj.org/end-palestine-genocide/
For lyrics to sing along!
And info on WHY we are caroling for Ceasefire and an End to Occupation.

Please share on socials and tag @ceasefirecarols @surjnnm @sfjp505

Visit Bethlehem 2023 Art Installation
Christmas Eve ONLY
During the Farolito Walk

Camino Monte Sol (300 block) between Canyon Rd and Acequia Madre

Scan to read artist's statement:
firstsevendesignlabs.com/bethlehem-2023/

Please share and tag @f1rstse7en, #Bethlehem2023, #BethlehemCanceledChristmas on socials
TAKE ACTION today and every day at uscpr.org/gazacall

We're riding again! Come all Ye Superheroes! Light up your bikes, finish all your Super Heroic Chores, and Celebrate the Full COLD Moon with us. We'll meet up 7pm at the Railyard Water Tower, and ride around at a social pace. At 7:30 we'll gather up the Loops: Santa Fe riders on The Plaza.

Event by Second Thursday Cycle Squad
Meetup at Railyard Water Tower
Duration: 2 hr

The Second Thursday of every month we bike through the city to a different brewery!
December - Second Street Rufina
January - Second Street Railyard
February - Santa Fe Brewing Brakeroom
All riders will get a raffle ticket for a gift card or swag, and REI Bike Tune-Ups!
Rain or shine, meet at 7 PM, ride out around 7:20
Ride distance: 5-8 miles (social pace)

I was given some apricot chutney, and it was so delicious I'm inspired to make some myself. I've done lactofermented things like hot sauce, kraut and kimchi. So I'm curious to access the Group Mind: What are your lactofermented chutney recipes, and tips for lactofermentation? :-D

https://lemmy.ca/pictrs/image/8053b6ac-d8b2-45d6-aeaa-360a1ceec17c.jpeg

Santos Rugby Annual Turkey Trot is Wednesday, 11/22, 6pm Brakeroom. Costumes preferred. Chug beers and run around Santa Fe like hooligans. (I'll be speed walking, I prefer not to throw up all of the beer I'm drinking)

Calling all Santas! https://www.santacon.info/Santa_Fe-NM/