Dominion works great 1v1 and scales up to 4 players in the base game, and up to 6 players with the Intrigue expansion or big box edition.
There are curse cards i.e. ways to reduce points from your opponent, but you can omit them from the game until you’re ready.
I also like to play these games 1v1:
- Colt Express
- Karuba
- Carcassone
Yeah they use ToxMod.