I don't fully understand what you mean.
With flatpak, you have the option of installing applications on the system (/var/lib/flatpak) or for a single user (~.local/share/flatpak). And application data for each gets stored in ~/.var/app.
AppArmor should confine the same regardless of which user is running the package. Besides, the flatpak's main sandboxing comes from bubblewrap. Though the distro's default AppArmor profiles can further be used to sandbox more stuff.
Oh I understand now, you're referring to making AppArmor profiles to target a specific app. I just did a little research and it's possible to create AppArmor policies for binaries that are in a user's home folder.
Rather than hardcoding a specific user's home, you can instead say "@{HOME}". So you could create a profile for "@{HOME}/.local/share/flatpak/app/appID/current/active/files/bin/binaryName" that would confine the app for all users.