this post was submitted on 04 Oct 2025
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Not sure if this is clear. Our bodies are supposed to replace all the cells every 7 or so years. Does that mean the fat too? Or when someone loses 20 year weight, are you getting rid of 20 year old fat?

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[–] TheRealKuni@piefed.social 25 points 15 hours ago (3 children)

When you gain weight your fat cells grow, and when you lose weight they shrink. You don't actually gain and lose fat cells the way people think.

But as my doctor explained to me, if they get big enough, they divide. Then even if you lose weight, you have fat cells hanging around who think they should be holding onto more fat than they are. So your body will want to be fat, and will enforce that with cravings.

It’s why it’s extremely hard to lose a large amount of weight and leave it off. I’m on my third major attempt now.

[–] jet@hackertalks.com 1 points 1 hour ago

The weight set point theory doesn't apply to low carbohydrate eating. The abundance of fat cells does not make people doing keto fatter. It's mostly the carbohydrate insulin model of obesity. Eating food that drives insulin makes people gain weight.

The abundance of active adipocytes can drive leptin issues, and aromatase issues. But as those adipocytes get emptied, there are no longer being as metabolically active and aren't an issue. Especially on low carbohydrate diets that don't drive elevated insulin levels

[–] dylanmorgan@slrpnk.net 16 points 14 hours ago (3 children)

Seems like that would be an argument for liposuction as a way to supplement other weight loss because it would remove those cells.

[–] TheRealKuni@piefed.social 8 points 14 hours ago (1 children)

I’ve had the same thought. Haven’t really looked into it though.

[–] volvoxvsmarla@sopuli.xyz 15 points 14 hours ago

I've studied nutrition science and we talked about what you described and yes, the blunt "truth" is that liposuction is the only reliable way to really get rid of "emptied fat cells". There are a lot of things playing into the dreaded yo yo effect but the fact that it is much easier to refill emptied cells than to make new cells via division is definitely a big factor.

("Truth" is in "" because I dislike this term in a scientific context but english is my third language and it's pretty late over here so I am struggling to find a better suited word)

Good luck on your weight loss journey. It is an incredibly hard and brave one to take and I admire that you are trying.

[–] Bubbaonthebeach@lemmy.ca 5 points 14 hours ago

I don't know much about liposuction but I believe it can only be done on subcutaneous fat (just under the skin) but not the deeper intra-abdominal fat that can be the cause of fat related health problems. If you can 'pinch' most of your fat then it is probably subcutaneous and lipo would help to remove the excess cells.

[–] Aussiemandeus@aussie.zone 3 points 14 hours ago (1 children)

It absolutely is. But I'm pretty sure it's expensive

[–] dylanmorgan@slrpnk.net 5 points 14 hours ago

And of course health insurance wouldn’t cover it because it’s “elective”.

[–] LavaPlanet@sh.itjust.works 7 points 13 hours ago

I've heard similar, that your body wants to keep the "norm" whatever that is. And it makes sense that any extreme weight loss, would seem, to your body, that there is a famine or something is wrong and then reset the balance back to what it was, as soon as it can.