I read this meme as a satire on the nature of graduate school research projects, where you often spend inordinate amounts of time repeating the same type of experiment in a variety of ways. This lets you publish either on the sheer body of work or, ideally, one of the products is particularly interesting and you get a bigger paper from it alone.

The "substrates" in this meme are odd and difficult to react, which again reflects many thesis projects. Also there are no stated goals and success is hard to measure or define.

Despite the absurdity of the scientific work, the subject still chooses to perform it even though they are deprived of real world relationships formed at Susan's baby shower and may also directly degrade their relationships with their Mom, brother's girlfriend, and dog because of it while also putting their health in jeopardy via cell alkylation.