That's a big question.

I've seen a lot of reports in the last couple of years where people have been saying that their ADHD meds aren't working the same or they aren't working at all. One person even discovered some old meds from the same manufacturer they had stashed away and they found that the old meds worked whereas the new meds didn't.

Not to discount people's experiences but the placebo effect is strong. Even when someone knows they are getting a placebo they can still get the effect. We can't rule that (and the nocebo effect) out in this case.

Often with generic medications or medications that different manufacturers produce, the medication will contain the same amount of active ingredients although they can be a different mixture of enantiomers, so it's the same molecule but it's either left-handed or right-handed (which itself is long story...) For most cases this doesn't make any difference but it can for some people. When it comes to amphetamine, there's a very clear difference between how the left and right-handed molecules work in the body but Adderall is set at a strict ratio of these molecules so, at least in theory, Adderall shouldn't have this problem.

The next thing down the list is the inactive ingredients - binders and fillers and all of that stuff. In theory these should have no impact on the medication because it's just stuff like cornstarch, talc, lactose etc. But without knowing the exact composition and doing rigorous testing it would be naive to rule it out as a possibility. Obviously different manufacturers will use different inactive ingredients because the only thing that the FDA or other regulatory bodies strictly monitor is the active ingredients.

The next thing is the biggest variable and that's the lifestyle factors for the individual. A change in diet, sleep disruptions, hormonal cycles, stress levels, other conditions like anxiety or depression, and a huge pile of other things can all have an impact on how effective ADHD meds seem to be and it's really difficult to control for all of this.

Idk what to say. Is it just a manufacturing mishap? Is there something fishy going on? Is it the placebo effect? It's impossible to tell without a lot more information.

I guess if I were in your shoes I'd probably try to get some Lannett manufactured Adderall and some Adderall manufactured by another company of the same dosage, then I'd set up a simple blind study - for the next 6 or 12 days put an equal amount of the two different Adderalls into separate cups or containers. Label the bottoms of each one to indicate whether they are Lannett or the other one but in such a way that you can't tell without looking at the bottom. Shuffle them so you don't know which is which. If the pills are visibly different then when you go to take one, close your eyes first. Each day record how effective the dose has been - you could do it on a scale of 1 to 10 or just something binary like effective/not effective or low/high effectiveness. I would also add in major details, such as if I had a terrible night's sleep or if I had an exam that day because I'd expect to feel less effect given those sorts of circumstances. Remember to label each container with the day of the week you took it on.

At the end of the experiment, match your day's effectiveness rating to the relevant container and the manufacturer. If you can identify a very clear split where the Lannett stuff really is less effective vs the other stuff then I'd really start investigating what's going on.

It's just hard to tell tbh. ADHD is a condition that shifts a lot depending on circumstances, stimulants are designed to have a relatively short period of effect (as opposed to say antidepressants or lithium where it has a very even, sustained effect), and there's a lot of variables to try and account for.

Don't take this reply as being dismissive of your experience or anyone else's - if I thought that this was a non-issue I wouldn't have bothered to write out all the other factors to take into consideration. Whatever is really going on here, the most important thing is to figuring what works best for your quality of life.