this post was submitted on 14 Jan 2025
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Summary

Bryan Johnson, a 46-year-old tech multimillionaire focused on anti-aging, stopped using rapamycin—a supplement he took for five years—after research suggested it might accelerate aging.

Johnson cited side effects like skin infections and glucose issues, as well as findings from a recent study showing rapamycin could worsen epigenetic aging.

Known for extreme anti-aging experiments, Johnson also created the health startup Blueprint, which markets pricey supplements.

His controversial methods, including teenage blood transfusions and genital shock treatments, have raised skepticism about their effectiveness and safety.

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[–] Allonzee@lemmy.world 60 points 4 months ago (3 children)
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[–] dhork@lemmy.world 40 points 4 months ago

Hah, sounds like his "research" is trying it out on himself and deciding he didn't like it. And now that he doesn't like it, all of a sudden he finds the research valid. He's still only listening to opinions he agrees with. What a shallow twat.

[–] Preflight_Tomato@lemm.ee 34 points 4 months ago (2 children)

Watched the documentary with a friend; we were trying to guess his age. We agreed on "decent looking for 55". He's 47 lol.

[–] ameancow@lemmy.world 21 points 4 months ago* (last edited 4 months ago)

People who are obsessed with some physical quality about themselves always make whatever the issue is, like 1000% worse than if they just left it alone and lived normally.

[–] Buddahriffic@lemmy.world 12 points 4 months ago (1 children)

His face looks old enough to make his hair look unnatural.

[–] apfelwoiSchoppen@lemmy.world 4 points 4 months ago

It looks like a wig.

[–] givesomefucks@lemmy.world 32 points 4 months ago (2 children)

Rapamycin

It's not just "one of many" it was the big one that has a large online following swearing by it, and lots of idiots taking it.

Also I can't see a pic of this guy without thinking of Dennis Reynolds asking if he should wear a mask of his own face.

[–] NocturnalMorning@lemmy.world 9 points 4 months ago* (last edited 4 months ago)

Every time I think of Dennis Reynolds, I'm reminded of the episode where he tries to sell his car that got stuck in water, and he berates the guy for mentioning how the car isn't even runnable.

[–] TachyonTele@lemm.ee 7 points 4 months ago (1 children)

Lol he even has "big hair". I bet this guy is a blast to be around. Yikes.

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[–] M0oP0o@mander.xyz 30 points 4 months ago (4 children)

"genital shock treatments"

Ok..... how did someone sell that as an anti-aging treatment?

[–] Uruanna@lemmy.world 19 points 4 months ago (1 children)

The salesman: "anti-what?"

[–] M0oP0o@mander.xyz 8 points 4 months ago

The passing of time must be stored in the balls.

[–] aesthelete@lemmy.world 10 points 4 months ago

I don't usually like salespeople, but this one I like a lot.

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[–] Fedizen@lemmy.world 27 points 4 months ago (1 children)

this guy sucks. He's conducting essentially a thousand uncontrolled trials on himself making them all useless unless he dies of a new contraindiction

[–] Free_Opinions@feddit.uk 15 points 4 months ago (2 children)

Why does he suck though? Aren't we all conducting uncontrolled trials on ourselves? Better that, than doing it on other people, right?

[–] NotMyOldRedditName@lemmy.world 13 points 4 months ago* (last edited 4 months ago) (1 children)

I think what they meant is even if he finds something that works, the data can't be trusted, which will heavily delay things like doing it properly.

[–] FaceDeer@fedia.io 8 points 4 months ago

If the tests aren't being done on anyone else yet then he's not going to delay anything by trying it himself.

Frankly, I admire his daring. When people pilot experimental aircraft or climb a mountain nobody's climbed before they're considered to be adventurers, he's doing the pharmaceutical equivalent.

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[–] GreenSofaBed@lemmy.zip 24 points 4 months ago (1 children)

I watched his video describing a day in his life, sleep at 8pm and wake up at 5am, then take 50 pills, his whole day revolved around preparing for sleep, which he said was the most important thing, so I guess he's right about that. But just thinking a tiny change in his life, even travelling, will upset this routine, then what, the stress from that routine is probably aging him the most.

[–] quixotic120@lemmy.world 17 points 4 months ago* (last edited 4 months ago) (1 children)

That’s the thing, he might live a bit longer but at what cost? I would much rather enjoy my life than by a slave to a miserable routine dedicated to promoting longevity that will potentially buy me an extra decade. Like I can just eat a somewhat reasonable diet, exercise, sleep okay and with decent genetics based on my parents and grandparents I will probably make it to at least mid to late 80s, maybe longer if medicine advances. If I had genetics that suggested a strong likelihood that I would die in my 60s I would maybe be more interested

With this guys routine I could maybe push that to 100ish? I would certainly love to extend my life but not at the cost of it consuming my life. I assume he’s banking on getting to the theoretical max though, which is probably closer to 120ish, and that is substantial but then it’s like a few decades of extremely decreased mobility and mental acuity? Eh

And of course this all disregards the potential that you get cancer, murdered, car accident, etc.

[–] TechAnon@lemm.ee 6 points 4 months ago

I truly believe he loves doing this so no cost to him as far as mental health/stress goes. Sounds like you are doing most things right so that pretty much covers the 80/20 rule. Johnson is trying to live indefinitely without losing mobility or mental faculties. It's great that we have someone testing things out and adjusting when things don't work.

[–] teft@lemmy.world 21 points 4 months ago (2 children)

I'm in my forties and he doesn't look noticeably younger than I do except for my hair being salt and pepper. I don't look exceptionally young or anything, it just doesn't seem like his regimen is really doing anything that diet, exercise, and sunscreen can't also accomplish.

[–] kamenlady@lemmy.world 19 points 4 months ago

I can imagine that having a hyperfocus on anti-aging and unstoppably aging at the same time, must be really stressful and at the end of the day, ends up contributing to a faster aging overall.

[–] exasperation@lemm.ee 6 points 4 months ago

Yeah I remember seeing some stupid post somewhere about this guy saying "can you believe this man is only 45" and everyone in the comments saying "um yes that is what 45 year olds look like."

[–] WhatSay@slrpnk.net 19 points 4 months ago

I bet I live longer than him, and on a shoestring budget

[–] yrnttm@lemmy.world 18 points 4 months ago (4 children)

This dude is just going to spend a bunch of money on shit that will eventually kill him. What a waste.

[–] aesthelete@lemmy.world 6 points 4 months ago

What an efficient allocation of capital!

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[–] apfelwoiSchoppen@lemmy.world 18 points 4 months ago (2 children)

The Dennis System for Aging

[–] PlasticExistence@lemmy.world 7 points 4 months ago

He just hit the final S in that system

He probably should have taken this medication under the supervision of Dr. Toboggan.

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[–] BigBenis@lemmy.world 18 points 4 months ago (1 children)

This guy looks like he's 60 cosplaying as a 20 year old

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[–] Scott_of_the_Arctic@lemmy.world 17 points 4 months ago

The guy looks like one of those Kraftwerk robots.

[–] jaybone@lemmy.world 16 points 4 months ago

Had to check this wasn’t nottheonion

[–] FundMECFSResearch@lemmy.blahaj.zone 14 points 4 months ago (2 children)

When you’ve got everything in life and all you want to do is live longer.

instead of helping the billions living in squalor and dying premature deaths.

[–] FaceDeer@fedia.io 5 points 4 months ago (1 children)

If he hits on an effective anti-aging treatment from his efforts then he'll help billions that way instead. Pretty much everyone eventually suffers from aging if they live long enough.

[–] FundMECFSResearch@lemmy.blahaj.zone 6 points 4 months ago (1 children)

I applaud your otimism in thinking it will be democratised and not a luxury for wealthy classes.

[–] FaceDeer@fedia.io 4 points 4 months ago

Almost all medications start out as a luxury for wealthy classes.

When insulin was first discovered as a treatment for diabetes the first Americans to be treated with it back in 1922 were James D. Havens, son of former congressman James S. Havens, and Elizabeth Hughes Gossett, daughter of the US Secretary of State. I can just imagine the Reddit threads at the time decrying how diabetes research was only benefiting the "elites." But nowadays insulin is manufactured in bulk and anyone can have access to it.

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[–] motor_spirit@lemmy.world 14 points 4 months ago

Lmao the picture of this dude is like Paul Rudd on Star Trek

[–] iAvicenna@lemmy.world 13 points 4 months ago* (last edited 4 months ago) (1 children)

Is this the trickle down economics everyone is talking about? shall we again start selling uranium, platinum etc beverages to the rich?

He has a team for this?

“Despite the immense potential from pre-clinical trials, my team and I came to the conclusion..."

Forget trickle down economics, this is insane just bring the guillotines.

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[–] disguy_ovahea@lemmy.world 11 points 4 months ago (1 children)

I still can’t believe he took his kid’s blood to try to live longer.

Is it wrong to wish him success in his quest for longevity with a side of quadriplegia?

[–] Aqarius@lemmy.world 10 points 4 months ago (1 children)

I see the proud tradition of drinking mercury concoctions is alive and well. I mean, not well, but...

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[–] dmtalon 9 points 4 months ago* (last edited 4 months ago) (1 children)

I ran across a YouTube video of this guy a couple months ago because a popular YT fitness guy (rock climber) I watch went and interviewed him and did some physical 'age tests' with him as well as just talk about his daily routines.

He doesn't come across as batshit crazy in the video, but obviously he's a bit obsessive over this whole thing.

The funniest part about it was that Magnus (Climber) matched or exceeded him in almost all the physical 'age tests' they performed. Of course, Magnus would also outperform most other people in most physical tests but that didn't make it any less humorous. On the "not as batshit as I imagined" list, he also seemed fairly supportive/genuine of Magnus' results/abilities during the video.

https://youtu.be/G7b28Vm9-O0

[–] dustyData@lemmy.world 4 points 4 months ago (2 children)

Regular physical activity and spending some time outdoors is more beneficial than injecting weird shit, who knew?

You can't fight bad habits with supplements.

[–] dmtalon 10 points 4 months ago

I don't believe this guy (Bryan) has a lot of bad habits, his whole life seems to revolve around this life extending plan. I'm not at all defending/justifying him, but he had a pretty good answer regarding what supplements are best when Magnus asked. His response was "The ones you are deficient in"

Again, as I said above, in the linked video he doesn't scream "batshit crazy" but just really eccentric!

[–] SkunkWorkz@lemmy.world 6 points 4 months ago

He also exercises and eating healthy though. He isn’t just popping pills and pray for the best.

[–] SnotFlickerman@lemmy.blahaj.zone 8 points 4 months ago* (last edited 4 months ago) (4 children)

genital shock treatments

We're going on a Holiday...

It's pretty wild someone like this is so high on his own supply that he bought into his own bullshit.

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[–] Mediocre_Bard@lemmy.world 7 points 4 months ago (9 children)

It would be hilarious if the societal collapse caused by wealth inequality resulted in him getting murdered. I would laugh and laugh.

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[–] hierophant_nihilant@reddthat.com 4 points 4 months ago

Well, aren't things peculiar in the Delusionland™️?

[–] ThrowawayInTheYear23@lemmy.world 4 points 4 months ago

Dude looks like he's in his late 50's

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