Yes it looks wonky because the perspective doesn't follow.
The sign's horizontal lines should be following the building's horizontal lines and they don't.
So either the sign is fake or the beam above the sign is not straight or the sign isn't straight and is tilted on one side.
As far as I know, that's not how epidurals work. Nothing goes to your brain. It just numbs the nerves in your spine and stops the pain signals from reaching your brain.