this post was submitted on 22 May 2025
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ADHD

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This could be a good new option for those with ADHD who are currently on meds for it.

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[–] N0t_5ure@lemmy.world 82 points 1 week ago* (last edited 1 week ago) (13 children)

This is really interesting. As I was reading the article I was wondering how they were going to wring money out of it, as amlodipine is off patent. Then I got to this part:

“While amlodipine shows promise in preclinical models, it is not currently suitable for use in ADHD in its marketed form,” Karlsson noted. “Further optimization through chemical modification is necessary to enhance CNS selectivity and ensure a favorable therapeutic index in the context of ADHD.”

Classic big pharma. Slightly tweak an existing drug in an insignificant way so that you can get a new patent on it and charge exorbitant prices.

[–] Uli@sopuli.xyz 10 points 1 week ago (5 children)

Is it going to still work on blood pressure? I don't like the idea of taking meds because I want to resolve things with diet and exercise when possible, and I'm afraid of side effects. But if I eventually have to start taking a blood pressure medication and the side effect is it makes my ADHD better, I could get on board with that.

[–] dumblederp@aussie.zone 3 points 1 week ago (1 children)

From what I understand about blood pressure, you should consider taking the meds now and then moving off them once diet and exercise have helped the situation. Hypertension is bad for you health.

[–] Uli@sopuli.xyz 3 points 1 week ago

That's a really good heads up. I hadn't thought about it much from that angle - that I might already be doing damage that's hard to reverse.

I got my blood pressure machine from the basement and the first reading was systolic 141 diastolic 78. But I had just climbed stairs from the basement. I sat for a couple minutes and now it's 115 over 75. Less anxiety inducing. Definitely something I should be tracking frequently and not have tucked away in the basement though.

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