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And don't take it the morning after a heavy night of drinking, it's like 10x more toxic in that scenario.
If you need a pain killer go for ibuprofen until like 24h after you finished your last drink
Wait fr? Wtf
Tylenol and alcohol are both processed through the liver and can harm it, especially when taken together, whereas ibuprofen ....
Okay I went to Wikipedia to check on the safety of ibuprofen with alcohol (bad idea, can cause gastric bleeding, just don't combine painkillers and booze in general) and I found out two (2) different things I found very interesting:
"Unlike most other NSAIDs, ibuprofen also acts as an inhibitor of Rho kinase and may be useful in recovery from spinal cord injury.[59][60] Another unusual activity is inhibition of the sweet taste receptor.[61]"
Hopefully I'll not need the first fact, but I'm all for anything that helps those who do.
And as a person with weight issues it's useful to me to know that second one so I don't sabotage myself!
Yeah that's a good call, definitely don't smash the ibuprofen, but I think one dose is generally pretty low risk, given I believe you still need to be overdosing on the ibuprofen to get problems, at least that's what a doctor told me when I asked a number of years ago.
The thing with alcohol and paracetamol/acetaminophen is it causes your liver to do something different than if you had the two separately. I'm not 100% I'm getting the terminology exactly right here but, If alcohol is taking up all of the "usual" enzyme a less efficient enzyme processes the paracetamol that's less efficient at metabolising it, that enzyme produces a toxic by-product that normally isn't created. That toxic by-product is what causes the liver failure if it can't subsequently be metabolised again quick enough.
A lot of things increase your risk of GI bleeding, it is a very serious danger but it's something you have to look at combinations of risk factors. I take high dose zoloft which increases my risk of GI bleeding and I drink socially, I never take more than a fairly low dose of ibuprofen or aspirin after drinking and I never take more than 200 mg of ibuprofen every 2 hours when not drinking, so far so good.
iirc the GI bleed risk is a standard NSAID thing. They cause your gastric and intestinal linings to grow slower, and since you need to constantly replenish that mucus. if it's not thick enough you get an ulcer.
standard not a doctor this isn't medical advice blahblah
It can damage your liver. Though some say it is greatly exaggerated when this discussion pops up online. But still I wouldn’t risk it.
I think advil/motrin is a safer NSAID if you are a drinker.