this post was submitted on 27 Nov 2025
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I’m interested in that feeling of relief some of us get after taking our estradiol dose. I experience it as intense relief that washes over me and bathes me in joy. My color perception dramatically improves at the same time, it’s a very sudden shift.

I seem to only experience it when my blood levels are too low and the new dose enters the blood. With Divigel it’s after 30 minutes have passed, in my case, but only if me levels are low.

Some questions I have:

  • If I don’t feel the relief, am I overdosed?
  • If I do feel the relief, am I underdosed?
  • Why do I and some feel the relief, while others have never felt it?

I don’t expect anyone to know the definitive answers, but maybe you can share your experience? I’m really interested in learning what this is all about.

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[–] Eladriagon@lemmy.blahaj.zone 1 points 4 hours ago* (last edited 4 hours ago)

Intramuscular formulations are designed to release into the bloodstream gradually over time, which is why most are designed for a dose (on average) every 7-10 days. This typically doesn’t present as a noticeable immediate “boost” in levels, but more of a gradual curve up and down.

I will say that days 2-4 for me (on a 7-day injection cycle) are definitely more full of energy and have more of a mood boost for me, as compared to other days.