squaresinger

Same here. I really should spend a few hours to finalize the tuning, but it prints ok enough that it's not really worth doing it.

People also still use Meta products, Apple products, Amazon and their products, and so on, even though all of these companies directly support the budding fascist empire in the USA.

Likely, you too buy/use products by a corporation that supports the pumpkin dictator, and that has much more real-world effect (on trans people and on all other minorities too) than the ramblings of a mad old TERF.

At least Rowling isn't directly stoking the genocide in Gaza or rounding up and deporting people to prison camps in other countries.

(I'm not defending Rowling. I'm just saying at a certain point most people, likely including you, value the convenience of next-day-shipping over the life of some people we don't know.)

Yeah, fair, I just wanted to make sure nobody has wrong expectations. Back when the Prusa Mini was new, off-the-shelf printers were much worse than they are today, and DIYing a printer could actually be a good deal if the goal was to have a good printer (and not specifically something to tinker with).

Nowadays, if you DIY a printer it's going to be more expensive while performing worse than an off-the-shelf printer.

Wayland has been around for many many many many more years than Wayland has been good enough to use. I think that’s about it.

I think that's mostly it. When Wayland was first released, it was barely in an alpha state, with many major use cases not being supported at all. Since Wayland is a deep system component, it requires apps to adjust to them, and in the beginning this hadn't happened at all so far, so really nothing worked.

And this didn't change over night. That easily took a decade, and still today some use cases still don't work well (e.g. accessibility/screen reader compatibility).

There's not a lot left from the original Ender 5.

I kept the frame and the steppers, belts and lead screw.

The wheel are replaced by MGN rails. The mainboard is now an Octopus v1.1. The print head is replaced with an E3D toolchanger with E3D v6 hotends, direct driven with TBG-Lite extruders. The toolchanger does bed levelling with a simple endstop mounted to the toolchanger in a way that it can reach the bed if all tools are parked.

The only remaining hardware issue is that I'd like to have a second Z motor.

I don't really consider my printer an Ender 5. It's more of a Ender-of-Theseus. It's basically a DIY design built on top of an existing frame.

But the real issue is software tuning. It's just so complicated and time intensive to tune all the dozens of parameters (speed, acceleration, linear advance, retraction, input shaping, auto bed levelling, tool offsets, ...).

Modern budget printers like the A1 are so amazingly good that matching their out-of-the-box performance and calibration takes a huge amount of time if it even is possible.

I easily spent 100+h reconstructing and tuning my printer, troubleshooting problems so obscure that I couldn't find anyone on the internet who talked about them before. Been working on this printer for about 4 years or so.

And the other day a friend of mine who received his A1 a week ago shows me the perfect quality multicolor prints that his cheapo A1 did after half an hour or so of setup.

Tbh, by now I would recommend against DIYing a printer.

I spent so much time on my fully-modified Ender 5 and it still doesn't print nearly as well or fast as a cheapo A1 Mini.

In panel 4 I first thought the woman has her hand up the cat's rear.

The version A) is a big issue actually, thanks to the Hoskins effect.

That means that if the immune system is trained for a slightly wrong type of pathogen, it might have a worse immune response to the actual pathogen at hand than if it wasn't trained at all.

So if that viral protein would mutate a bit, so that it's still recognized as viral protein by the immune system, it might cause the immune response to the actual virus to be worse instead of improving it.

Die EVP ist deiner Meinung nach nicht rechts?

https://de.wikipedia.org/wiki/Europawahl_2024

Es gibt 720 Sitze, die Mehrheit hat man also ab über 320. EVP + PfE + EKR + ESN haben zusammen 375 Sitze.

Die Rechten haben gerade jetzt im Moment eine Mehrheit im Europaparlamant.

The reason why I thought about harmful mutations in this context is because this strain of yeast has some kind of property that activates the immune system, otherwise the whole concept wouldn't work.

That's not something regular yeast does, so for regular yeast to evolve something like that, that's a major step in evolution that doesn't happen quickly.

But modifying the immune system activating payload is much less difficult.

Due to the Hoskins effect, it's possible that an immune system trained for a "somewhat wrong" pathogen can perform worse than one that hasn't seen that kind of pathogen at all before. So if the payload of the yeast mutates, it can "mistrain" the immune system so that it then performs worse on the real-life pathogen.

The difficulty I see here is that it took the yeast not very long to mutate a beneficial effect, but it could just as quickly mutate away from that and even mutate something harmful.

The biggest cost factor for classical pharma is QA. Both in the form of certifications before release and in the form of regular QA during production.

So skipping QA can of course bring the cost down massively, but with the cost of making a potentially very dangerous product.

Peasant in wicked cosplay? That would be a fun NPC.