this post was submitted on 02 Oct 2025
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I've been on HRT for 6 months, with 5mg weekly injections for the last 3 of those months.
3 months ago, my E was 22 pg/ml, now it is 333 pg/ml.
Doctor says that is too high and is going to to reduce me to a "maintenance dose". Just wanted to check with other people if this is consistent with their experiences. Thanks!

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[–] Tencho@lemmy.world 2 points 3 days ago (1 children)

seems like you know a lot about this.

I'm personally sitting somewhere in the 400-500pg/ml range as its where my energy is the highest. I'm doing monotherapy indefinitely.

would you suggest i try to prioritize surgery so i can reduce my levels?

Really im just curious what time frame a "temporary monotherapy" counts as.

[–] dandelion@lemmy.blahaj.zone 1 points 3 days ago* (last edited 3 days ago) (1 children)

yes, I highly recommend an orchiectomy from a skillful surgeon, ideally someone that also performs vaginoplasties (so they are more likely to know how to preserve options for a future vaginoplasty if that becomes a possibility and desire later).

The temporary timeline was at most a year, since in the U.S. insurance requires a minimum of 1 year on supervised HRT before allowing any trans gender-affirming surgeries.

Anecdotally, I never found monotherapy as stable for my mood as having more normal estrogen levels post-op, but most of the stability just came from my body no longer occasionally producing testosterone levels I didn't tolerate well. (High estrogen definitely made me more emotional, but in some ways I enjoyed how it felt - once my life calms down enough, I plan to incorporate occasionally more frequent or higher doses to simulate a monthly cycle.)

[–] Tencho@lemmy.world 2 points 2 days ago

Simulating a monthly cycle sounds kinda fun. I hope I can do that in the future too!

Still just a baby trans girl tho. I'm amazed at how big of a difference a little estrogen has done for me.

I'll look into orchie, I don't think i want a vagina but idk maybe its worth keeping the option.

Thanks!